Best Natural Brain Supplements

Quarantine has us all feeling low and unmotivated to even move from our beds. With piles of school and office work, everything seems to be getting harder and messier. Want to get a little push to get up and start your day and do all the pending tasks? Get your hands on some best natural brain supplements. 

Brain supplements are brain boosting supplements that can help you with the betterment and improvement of the brain and related functions. Not only are they useful as everyday supplements but they have been seen to really help by slowly treating or delaying the early onset of several cognitive disabilities. 

With all the benefits, let’s take a look at the best natural supplements in 2021!

Our Overall #1 Rated Pick

Mind Lab Pro

  • Avoids anxiety
  • Supports immune system
  • It boosts energy

Mind Lab Pro is a safe and pure brain supplement. It contains all-natural ingredients and no artificial mixings. The supplement is a decent pick for healthy brain growth. The brain controls most of our actions and reactions. 

As we age, the brain loses its health. That is why these supplements are essential for brain health. Mind Lab Pro supports the nervous system and immunity system. It builds a wall that protects the brain from diseases.

Need more detail? Read our Mind Lab Pro review for a complete breakdown.

The 10 Best Natural Brain Supplements in 2021 – Comparison Table




Best Natural Brain Supplements in 2021 – Product Review

Top 10 Natural Brain Supplements in 2021 out there

Mind LAB Pro

Mind Lab Pro is a safe and pure brain supplement. It contains all-natural ingredients and no artificial mixings. The supplement is a decent pick for healthy brain growth. The brain controls most of our actions and reactions. 

As we age, the brain loses its health. That is why these supplements are essential for brain health. Mind Lab Pro supports the nervous system and immunity system. It builds a wall that protects the brain from diseases.

The supplement contains plant-based ingredients. It has a nice blend of nootropics and bio-pathways. The nootropics are effective to boost the energy of the brain. It promotes effective brain performance. The bio-pathways in the supplement provide mental clarity.

The supplement is tested and distilled molecularly. It is free of chemicals, metals, and other toxins. The supplement acts fast. It enhances the sleep pattern of the body and reduces stress. The supplement heals, restores, and repairs brain cells.

The ingredients of the supplement are non-GMO confirmed and dairy-free. It also supports the digestive system and heart health.


  • Completely organic 
  • Boosts cognition
  • Reduces stress and inflammation
  • Provides energy 
  • Supports immunity 
  • High potency


  • None

Performance Lab Mind

Performance Lab Mind is a new and effective brain supplement. It contains essential nutrients and vitamins for healthy brain growth. The supplement contains clean, pure, and safe ingredients. The brain tends to get weak as we grow old. 

The ingredients of the supplement are verified non-GMO, dairy-free, and allergy-free. It is distilled properly. So, there are no metals, toxins, and chemicals are present. It has no preservatives, pesticides, and synthetic flavors.

It is easy to swallow as there is no after-taste. The supplement promotes relaxation of the mind. It increases cognition and focus. The supplement is good for brain health. It prevents brain fog and memory loss. 

The prebiotics in the supplement maintain digestive health. Performance Lab Mind has essential ingredients to restore the brain chemicals. It provides energy and speed to the brain. Moreover, it heals the cell membrane.

The ingredients are 100% plant-based and verified safe. It is good for daily use, as it reduces stress, depression, and anxiety. The capsules are also tested twice for safety.


  • Organic 
  • Supports Immunity system 
  • Calms stressed joints 
  • Maintains heart health
  • Improves sleep pattern
  • Reduces anxiety


  • None

Performance Lab Caffeine +

Performance Lab Caffeine +

Performance Lab Caffeine + is one of the most effective brain supplements. It is all-natural and safe to use. The brain is a delicate and complex part of our body. It is essential to take care of it as the brain controls most of our actions. 

Performance Lab Caffeine + is verified safe to use. The supplement is 100% organic. It is tested twice to ensure that the product is up to quality. Moreover, it is free of metals, toxins, and other pollutants. The ingredients are non-GMO, soy-free, and allergy-free. 

It supports the nervous system and boosts the immune system. The supplement protects the brain. It prevents brain fog and memory loss. The brain gets weak as we age and supplement is essential for a healthy brain.

The ingredients are free of artificial caffeine, chemicals, colors, flavors, sweeteners, and preservatives. It helps to maintain heart health and blood sugar levels. The supplement is also effective for chronic pain, stress, and depression.

Its primary purpose is to enhance brain performance and cognition. The supplement supports critical thinking, mental clarity, concentration, and focus.


  • Improves clarity 
  • Reduces fatigue and insomnia 
  • Relieves pain 
  • Provides energy 
  • Enhances brain routine 
  • Vegan-friendly


  • None

Spruce 750 mg CBD Oil

The brain is a delicate organ of the human body. It controls and manages most of our daily tasks. Brain supplements are essential as they boost the brain’s energy. These supplements support the brain’s immunity system.

Spruce 750 mg CBD Oil is an essential pick as a natural brain supplement. It contains supporting nutrients, vitamins, and minerals for healthy brain growth. The oil is also packed with safe, pure, and clean ingredients. 

The oil contains hemp extract. It is acquired from large organic farms. The process is necessary to keep the value of the hemp high. Moreover, hemp extract is essential for relaxing the body. The CBD Oil is verified and verified safe to use. 

It is certified safe by the local lab scientists and also by an independent party. The testing is important to maintain the credibility of the buyers. It is good to pick insomnia, pain, inflammation, and the brain. The oil reduces stress and lowers the chances of memory loss. 

It contains non-GMO certified and dairy-free ingredients. The oil is also free of any kind of alloys, dirt, chemicals, and pollutants. It dissolves fast into the bloodstream.


  • The oil is plant-based 
  • Full-spectrum 
  • Cruelty-free
  • Verified safe to consume 
  • Pure and clean 
  • Improves cognition 
  • Improves sleep rotation 
  • Reduces stress and inflammation


  • It is not THC-free. The quantity might get you positive for drugs

Spruce 2400 mg CBD Oil

Spruce 2400 mg CBD Oil is effective and efficient for brain health. It is a natural oil which is a good thing. The oil is full of safe, legal, and lean ingredients. The brain is complicated and a delicate organ. It is important to take care of it.

The brain is responsible for most of our actions and intelligence. These supplements support the brain’s immunity and provide energy. The oil contains vitamins, minerals, and other nutrients for brain health. The hemp in the oil is acquired from farms.

The hemp is essential for body relaxation and calmness. It has a unique consistency and formula. The oil liquefies into the bloodstream as soon as it is consumed. The oil prevents sleepless nights and lazy days. You will feel better after regular use. 

The oil is verified in small batches. It is certified safe to consume by an independent company. The oil is free of metals, compounds, and toxins. It is also free of preservatives, additives, sweeteners, and flavors. The oil is a good addition for reducing pain and stress. 

The hemp in the oil is acquired from the farms under CO2 extraction. It is a safe procedure to maintain hemp quality and effectiveness. The ingredients are non-GMO certified, dairy-free, and allergy-free. Moreover, the oil is cruelty-free and full-spectrum.

The oil supports the nervous system and enhances cognition. It improves mental clarity and focuses.


  • Natural 
  • Extra strength 
  • Full-spectrum 
  • Confirmed safe to use 
  • Supports immunity 
  • Provides energy 
  • Enhances sleep cycle


  • It contains THC

Spruce 4800 mg CBD Oil

Spruce 4800 mg CBD Oil is of high potency. It acts fast and absorbs quickly into the bloodstream. The oil is a good pick as a natural brain supplement. As we age our brain ages too. It is important to feed healthy nutrients and vitamins to the brain.

Spruce CBD Oil is a good choice. It improves mental clarity, concentration, and cognition. The oil has no specific taste and smell. You can add it to any food or beverage of your choice. The oil provides strength to the brain’s immunity wall.

The hemp in the oil is obtained from organic farms. The procedure maintains and controls the value of the hemp. It is an essential ingredient of CBD Oil. It provides relaxation to the mind.

The oil is verified twice for safety and to ensure its quality. It is tested during manufacturing and at the end. The oil is also verified safe by an independent company. Lab reports are available to the public. The oil is lab-grade and contains safe ingredients.

The ingredients are free of preservatives, pesticides, and sweeteners. It is distilled properly. The oil is free of metals, toxins, and other chemicals. The oil is full-spectrum and contains THC. However, the amount of THC is very low.


  • Pure and safe 
  • Vegan-friendly
  • High potency 
  • Improves sleep 
  • Supports immunity
  • Full-spectrum


  • It contains THC

Spruce 400 mg CBD Oil

Spruce 400 mg CBD Oil has similar properties as other CBD Oils. The only difference is that it is a sample size oil. The oil is designed for people who are not familiar with online buying. The oil is high in strength and supports the nervous system.

The hemp in the oil provides relaxation to the mind. It is good for preventing insomnia and fatigue. Our brain is always busy doing different tasks. It is important to take care of it. That is why these supplements are essential for healthy brain growth.

The oil is verified and verified safe to consume. It is tested twice in the lab. The oil is verified by an independent company. It is important to maintain the trust of the people. The oil is filled with non-GMO, soy-free, and dairy-free ingredients. 

The oil is free of metals, compounds, and toxins. It supports the immunity system and digestive system. The oil enhance sleep pattern and cognition.


  • Organic
  • Vegan-based
  • Improves sleep 
  • Supports immunity 
  • Extra-strength 
  • Improves cognition


  • It has THC
  • The serving size is small

Cheef Botanicals CBD Oil

Cheef Botanicals CBD Oil is an effective choice as a natural brain supplement. CBD Oil contains all-natural ingredients. It is distilled and certified safe to use. The oil is verified during manufacturing and also at the end.

It is also verified safe by an independent company. These tests are essential to maintain the brand’s credibility. It contains hemp extract acquired from organic farms. The hemp is essential to provide relaxation to the mind. 

The oil is packed with non-GMO, caffeine-free, preservative-free, and allergy-free ingredients. Testes of the oil are available for the public. Oil is free of metals and toxins. The oil is full-spectrum and vegan-friendly.

Cheef Botanicals CBD Oil is not entirely free of THC. However, the amount is very low. It will not cause addiction. The CBD Oil enhances mental clarity and focus. It also boosts the energy and immunity of the brain.


  • Organic
  • Verified safe to use 
  • Tested 
  • Full-spectrum
  • Enhances brain actions
  • Strengthen brain nerves 
  • Lowers fatigue and insomnia


  • None

Best Natural Brain Supplements in 2021 – Buying Guide

With all the benefits, it would be best if we can find a supplement that is 100% natural. Lucky for you, there are a lot of companies that offer organic and natural nootropics. This buying guide will help you know what ingredients are the best additive in a brain-boosting supplement. 

Ingredients in the Best Natural Brain Supplements

  • Fish Oil

First of all, we have fish oil. Fish oil with its omega content has been proven to be an incredible nootropic. The omega content, namely both DHA and EPA, has been seen to provide a lot of positive functions including anti-inflammatory properties and improved learning capabilities. 

DHA deficiency has been seen quite commonly, especially in teenagers and old people. This deficiency can lead to several frustrating outcomes such as memory decline and difficulty in concentrating. Adequate regular intake of DHA in the form of fish oil helps in protecting and improving brain functions.

Along with that, DHA and EPA have also been discovered to play a vital role in the preservation of brain health and memories which usually declines with age. 

  • Resveratrol

Resveratrol is a naturally occurring antioxidant that is usually found in fruits, mostly berry. Resveratrol is one of those ingredients that you will find in every other brain-boosting supplement due to its incredible properties. 

This antioxidant has protective properties that prevent brain deterioration, mostly in the hippocampus, that occurs due to either some disease or just aging. Although there has not been enough work done on human volunteers to state confidently all the effects and side effects of Resveratrol. 

But, human survey studies and animal model studies have shown the positive impact that Resveratrol has on the brain. 

  • Caffeine

Yes, caffeine. It is a naturally occurring brain stimulant. Now, you must be wondering, isn’t coffee bad for you? When taken in higher doses, yes. But in nootropic supplements, the caffeine amount is so little that it is not enough to cause any type of side effect. A stimulant is needed in brain boosters to help wake you up and give you that burst of energy that you need to get done with your tasks. 

Studies have shown that caffeine will help you feel more energized and awake and it will help improve your memory as well. The safe and beneficial dose of caffeine is 200 mg per day. This amount will give you all the benefits and none of the side effects.

  • Phosphatidylserine

Phosphatidylserine is a phospholipid that is naturally occurring in the human brain. One of the main functions of this phospholipid is to wrap the brain in a protective layering and make sure nothing damages the brain. 

In short, Phosphatidylserine has preservative qualities that will ensure the proper working and overall health of the brain. Studies have also concluded that Phosphatidylserine can also help with the memory loss and brain health decline that comes with old age. 

Phosphatidylserine has a lot more potential but due to limited studies, not a lot can be said about the Phosphatidylserine properties. A regular 100 mg dose of Phosphatidylserine is deemed both safe and beneficial for cognitive health. 

  • Acetyl-L-Carnitine

Acetyl-L-Carnitine is an amino acid that is already found in the human brain. This amino acid plays a vital role in overall brain health and contributes to the wakefulness and activeness of an individual. Trial studies have shown that the regular intake of Acetyl-L-Carnitine helped the volunteers in memory strengthening, induce alertness, and delay in age-related cognitive diseases. 

A study with human volunteers has shown the effects of Acetyl-L-Carnitine on age-related cognitive problems. According to the study, Acetyl-L-Carnitine supplements slow down age-related cognitive impairment, such as Alzheimer’s. 

Other than that, Acetyl-L-Carnitine supplements were also seen improving the learning capabilities of the consumers. 

  • Ginkgo Biloba

Ginkgo Biloba is a natural supplement additive that originated from a tree named Gingko. Ginkgo herbal supplements have been around for a while and have been known for their brain-boosting properties. The mode of function of this herb is thought to be “improving focus and memory by getting the blood rushing to the brain.” 

Due to the lack of any real proof of its said properties, several trial studies have jumbled conclusions. This makes it hard to come to a definitive and solid conclusion. A lot of studies have reported that Gingko did help with cognitive health and improvement in age-related problems. 

  • Creatine

Creatine is an organic compound that is naturally occurring in the human body. It plays a vital role in energy utilization and is usually found in the muscles. Creatine in supplements is taken from animal sources usually such as milk and egg. 

Studies have shown that a good level of Creatine can improve the memory and thinking properties of consumers, especially vegans. A study with vegan volunteers showed improvement in the memory and intelligence of the consumers by a total of 25%. 

The reason for such a huge improvement is that vegans are usually deficient in Creatine due to a lack of meat and dairy product consumption.

  • Ashwagandha

Ashwagandha is a naturally occurring medicinal herb, native to South Asia. This herb and its medicinal properties have been known and studied for such a long time. All the properties of Ashwagandha are in line with the properties of a nootropic. 

This herb has anti-anxiety and anti-stress properties along with anti-inflammatory properties. One of the main benefits of this herb lies in its property to reduce the amount of amyloid-beta in the brain. Amyloid beta is a peptide that is seen in patients who suffer from Alzheimer’s. 

Reduction of the amount of amyloid-beta leads to improvement in memory recalling in Alzheimer’s patients.  

  • Bacopa

Bacopa, also known as Brahimi, is a natural herb, originating from a plant named Bacopa Monnier. This herb is being used as a nootropic way before the word nootropic was coined. Since it’s a medicinal herb, it has several healing properties that are backed up by science and research. 

Bacopa has antioxidant, hepatoprotective, and neuroprotective properties, all of which solidify its potential as a brain booster. It has also been seen to boost the production of dopamine, serotonin, and neurotransmitters. 

This way, the regular intake of Bacopa can help improve the mood shifts, focus, and wakefulness of the consumer.

  • Citicoline

Citicoline has been known to be the best nootropic additive. It is an intermediate of phosphatidylcholine. Citicoline has a wide list of benefits including memory improvement and focus enhancement. 

Several trial-based pieces of research have shown that the regular and contained dose of citicoline to human volunteers showed great cognitive improvement. Memory, focus, and energy-boosting are the main benefits of the citicoline and are heavily backed up by scientific trials and research. 

Other than cognitive improvement, people who suffer from insomnia, stress or fatigue, can benefit from citicoline as well. 

  • Curcumin 

Speaking of natural brain booster, turmeric is really up there. Turmeric has an antioxidant compound called curcumin which is believed to improve focus and learning and helps improve mood. Curcumin has quite a bit of beneficial properties such as antioxidant and anti-inflammatory properties. 

One of the main benefits of curcumin is its ability to reduce the amount of beta-amyloid.  The reduction of beta-amyloid plays a vital role in the treatment of Alzheimer’s. Other than the actual help with the cognitive disease, curcumin also has protective properties that prevent the brain from any neuron damage.  

  • Folate

Folate is a vitamin and is commonly known as vitamin B9. So, how does it help the brain-boosting? Folate acts as a coenzyme and helps the brain in the production of a chemical S-Adenosyl Methionine that helps with cognitive health. 

Folate has a big role in the optimization of the brain. This vitamin plays an important role in several cell functions. Folate also helps to boost the production of serotonin and dopamine which not only lift the mood and prevent the mood swings but also helps the neurotransmitters with better connections between the body and the brain.   

  • Magnesium 

Although magnesium is pretty abundant in the body, magnesium deficiency is pretty common. Magnesium plays a vital role in cognitive health. It helps the brain feel more active and awake as magnesium helps in the production of ATP, which is an energy molecule. 

Other than that, Magnesium also helps the flow of neurotransmitters by regulating the ion channels.  Magnesium also helps with neuroprotection and energy-boosting properties. Also, magnesium helps the neuroplasticity functions which in turn helps the learning capabilities and memory retention.

  • Melatonin

If you suffer from insomnia, there is a good chance that you have heard of melatonin. It is a hormone naturally present in humans that regulates the sleep cycle. This sleep hormone decreases with age and has been seen to not only affect the sleep cycle but is also responsible for age-related cognitive and memory decline. 

Melatonin is also an avid antioxidant and reduces the production of free radicals in the brain. Melatonin has also been seen to act as a neuroprotective agent as it protects the neurons and keeps the brain free of toxins and free radicals. 

  • MCT 

MCT or medium-chain triglycerides are called a mind fuel that is both quick-acting and effective. Few of the functions include heightened alertness and boosted cognitive functioning. MCT oils have been seen to affect ketones production which leads to several positive outcomes such as increased ATP and improved memory. 

MCT has also been seen to affect the moods and oxidants present in the body in a more positive manner. For Alzheimer’s, one of the main reasons for brain deterioration was the inability of the brain to take up glucose for the sake of energy. 

Ketones, due to MCT, were able to present themselves as an alternate source of energy to keep the brain healthy. 

Best Natural Brain Supplements in 2021 – FAQs

Q. Are there any side effects?

Upset stomach and diarrhea are the most commonly reported side effects. Side effects mostly depend on ingredients. If you know certain ingredients won’t work for you, you can always opt for some other brand.

Q. Are natural nootropics really natural?

You need to check the source of ingredients to make sure they are in fact natural. A lot of companies will have a website that will elaborate their source. 

Q. Are nootropics FDA approved?

Not yet. These brain boosters are not FDA approved but are tested by a 3rd party to ensure a clean manufacturing process and pure product. 

Best Natural Brain Supplements in 2021 – Final Word

With time, brain boosters have gained such momentum in both sales and their popularity. People are becoming more and more aware of their health and want to take care of themselves and improve their lifestyle. 

Nootropic inclusion in your daily regime may seem like a small step but can really make a huge difference. A lot of nootropic companies have claimed that consumers will be able to see the result in one day. With so many natural and even vegan options available, there is really no room for hesitation. 

These supplements are safe, natural, and effective in most sense. Get your very own best natural brain supplement today and take one more step towards a healthier you!